In the cannabis market, new products appear every. This also extends to products for use on the skin such as creams for cutaneous use. Now, as we know, CBD from cannabis is used in hemp oil, taking advantage of the fact that it is a non-psychoactive compound. It has also been used for a long time for its therapeutic benefits, including soothing the skin, treating joint injuries and relieving chronic pain. Many studies have confirmed these thoughts made by traditional cultures for thousands of years.
A 2014 scientific report found that due to its anti-inflammatory effect and sebum-reducing properties, CBD can help treat acne-prone skin. In addition, the results of multiple trials have also concluded that CBD strongly regulates the proliferation, migration, and neurogenesis of Mesenchymal Stem Cells (MCS). These adult stem cells can differentiate into major precursor cell types and have demonstrated anti-inflammatory, immune, metabolic, and self-renewal properties.
Dermatologists agree that the anti-aging and anti-inflammatory benefits of CBD are clinically proven. Hemp CBD oil is reputed to be the more established oil derived from the vegetable kingdom, so it is less porous and it does not clog the skin. On the contrary, it generates a moisturizing effect for dry and cracked skin.
Most CBD oil-based beauty products are legally available for shipping to most states in the USA and to a large number of countries around the world. These products must have a THC concentration of less than 0.3 mg. Some CBD products contain zero THC which is considered very positive as it allows the product to be in compliance with the regulations of many countries.
Use of cannabis in dermatological treatments
Because the Central Endocannabinoid System plays an important regulatory role in the skin, it is plausible that topical cannabinoid treatment is effective for certain disorders or for skin health in general. However, most of the clinical evidence to date has focused on the effects of CBD and other cannabinoids when consumed, inhaled, or injected. There is limited research investigating the therapeutic potential for topical applications. However, there is evidence to suggest that topical application of cannabinoids, and specifically CBD, may be a viable route of administration for certain conditions. Although CBD has a reasonable molecular weight (314.46 Da), its high log P value (lipid partition/water) of ~6.3 poses unique challenges for transdermal administration. However, this challenge can be overcome if appropriate transport systems are used as seen with transcutaneous absorption of CBD in preclinical models.
In 2003, Lodzki et al reported successful transdermal administration of CBD in a murine model using ethosomal carriers. Similarly, Hammel et al investigated the efficacy of topically applied CBD (1-10%) in gel format, specifically for the reduction of inflammation-associated symptoms in a monoarthritic rat model and found that it was well absorbed as the plasma concentration showed a linear relationship with the applied dose. In vitro diffusion studies with human tissue have demonstrated the penetration potential of CBD. No clinical trials investigating the topical absorption capacity in humans have been identified. More work is warranted to better understand the appropriate dosages and delivery methods for therapeutic skin applications of CBD.
CBD and cannabis for Eczema or Atopic Dermatitis
As we have already pointed out, CBD-based cannabis creams can help people with chronic skin problems. Atopic dermatitis (AD) manifests as a chronic inflammatory skin disorder associated with multifactorial causes such as environmental triggers, impaired skin barrier function, microbiome imbalance, genetic predisposition, and an altered immune response. Atopic dermititis can also be treated with cannabis.
This is because phytocannabinoids have been shown to modulate inflammatory responses by regulating more than one underlying mechanism. Also, adelmidrol, a PEA derivative, has been shown to be effective in treating mild AD in the pediatric population. CBD has been shown to exhibit anti-inflammatory properties in an experimental model of allergic contact dermatitis.
The influence of microbiome imbalance, especially due to Staphylococcus aureus (S. aureus) colonization and biofilm formation, has also emerged as an influential factor that may contribute to dermatitis severity. Preliminary data indicating the antimicrobial and antibiofilm activity of hemp comes from the fraction of essential oil (steam distillate) of hemp which is mainly composed of terpenoids such as myrcene, α-pinene, β-caryophyllene and other terpenes, but not significant levels. of CBD. Zengin et al evaluated the antimicrobial and antibiofilm efficacy of hemp essential oil (EO) against a reference strain (S. aureus American Type Culture Collection (ATCC), and three clinical strains.
Hemp EO values of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum biofilm eradication concentration (MBEC) against all types of S. aureus strains were reported as 8, 16, and 24mg/mL, respectively, which indicated that hemp EO can disrupt and eradicate a mature S. aureus biofilm. Therefore, the antimicrobial and antibiofilm activities of hemp EO against S. aureus suggest its therapeutic potential to prevent skin disorders such as atopic dermatitis.
Cannabis and oral skin care
There are few studies related to the use of cannabis and oral care. In the 1950s, topical preparations of cannabis sativa were discovered to contain antiseptic properties against various lesions of the skin and oral cavity. Now, the seed oil has showed its antibacterial qualities, but is ineffective against fungi. Also, ethanol and methanol extracts from cannabis leaves and stems were tested against different microorganisms. A significant inhibitory effect was observed in the ethanolic extracts of cannabis sativa leaves with zones of inhibition.
The aqueous and acetone extracts of the cannabinoids demonstrated high antimicrobial activity, showing clear zones of inhibition against the bacteria Pseudomonas aeruginosa (3–8 mm), Vibrio cholerae (4–10 mm), the fungi Cryptococcus neoformans (4–10 mm), and Candida albicans (4–12 mm). It should be noted that hemp seeds and stems contain almost no CBD content while other parts of the hemp plant contain significant amounts of CBD and other cannabinoids.
In 2019, a study was conducted to evaluate the efficacy of cannabinoids (BGA, cannabigerolic acid; CBN, cannabinol; CBG, cannabigerol; CBD and CBC, cannabichromene) compared to commercial oral care products. Cannabinoids were more effective in reducing the bacterial content of dental plaque compared to commercially available synthetic oral care products. Therefore, natural cannabinoids may have the potential to be used as an effective treatment to eliminate oral bacteria associated with dental plaque and provide a safer alternative to synthetic antibiotics.
Cannabis and skin pigmentation in humans
Now, if we talk about cannabis and its use for pigmentation problems, we can say the following: Human skin pigmentation is the manifestation of the synthesis of a dark pigment, melanin, which is regulated by a melanogenesis process in melanocytes. Melanogenesis is a complex process regulated by more than 250 genes. The factor of Microphthalmia transcription inhibitor (MITF) acts as a master regulator of melanogenesis, directly controlling the transcription of key genes involved in pigmentation such as tyrosinase (TYR), tyrosinase-related protein (TYRP)-1, and TYRP-2.
Due to a limited number of studies, the involvement of the ECS in the cascades of the melanogenesis process is unclear. In 2012, Pucci et al showed that a fully functional ECS was present in normal human primary epidermal melanocytes. Lower concentrations of AEA as well as other endocannabinoids such as arachidonoyl-2′-chloroethylamide (ACEA) and 2-AG demonstrated dose-dependent induction of melanogenesis through the CB1 receptor. However, other studies demonstrated contrasting results with CB1 agonism that inhibits melanogenesis or has no influence. Zhou et al demonstrated that OEA acts as an inhibitor of melanin synthesis and MITF production in α-MSH-stimulated B16 cells through activation of the ERK, Akt, and p38 pathways and inhibition of the CREB pathway.
Another study by Magina et al showed that CB1 agonism, under UVB exposure in a coculture model using HaCat cells and SK-mel-1, inhibited basal melanogenesis. Whereas, the inhibition was reversed when a CB1 antagonist was introduced. Kim et al showed that a major metabolite of JWH-073, a synthetic cannabinoid, had no significant effect on hair pigmentation. Unfortunately, there are limited studies on the effect of phytocannabinoids such as CBD on melanogenesis. Hwang and colleagues showed that CBD stimulates both melanin content and tyrosinase activity, mediated by CB1 receptors in human epidermal melanocytes. The melanogenic effects of CBD occur primarily through MITF upregulation which is mediated by activation of p42/44 MAPK and p38 MAPK signaling.
The involvement of ECS pathways in melanocytes is highly complex and unclear, thus requiring further investigation with various in vitro and in vivo models. Although endocannabinoids are potential mediators for healthy and diseased skin, it is thought to be premature to target pigmentation disorders using cannabinoids.
The most used cannabis strains for therapeutic skin creams and oils
In this article, we have talked about different skin pathologies that can be treated with cannabis and we have highlighted that some cannabinoids such as CBD and CGB can help relieve pain and control skin problems thanks to their medicinal effects. Now, we are going to share the main varieties of CBD-rich cannabis that are used to make different types of creams that help the skin. Remember to always consult your doctor before using a strain of weed to make creams, oils, or extracts.
Lavender is a mostly sativa feminized seed that stands out for its lavender herbal flavors with sweet notes and hints of wood and spicy touches. This cannabis strain is fast flowering because it requires only 50 days from the appearance of the first pistils to harvest. Also, the heavy yields that it delivers stand out, delivering about 500 gr/plant of resinous buds outdoors and about 450 gr/m2 of compact and hard buds indoors.
Terpenes such as humelene stand out in this variety of weed which has sedative properties that can help control pain that is affecting the skin. But, that’s not all because, humulene functions as an antibacterial agent and has antineoplastic and anti-inflammatory properties. In small amounts, it has been shown to kill S. aureus bacteria. In addition, Lavender produces effects that are calming and help control arthritis, insomnia, and anxiety.
CBD ACDC 1:18
Many brands of therapeutic cannabis-based creams and oils use the CBD ACDC 1:18 strain, a hybrid-type weed variety that contains CBD levels of 20%-28% with low THC levels that only reach 0.5 %-0.08%. To the above, it must be added that the flowering is only 8-10 weeks. For the same reason, it has a flowering period between short and medium which makes it ideal for growers who want to harvest quickly and later make their extracts, including oils or therapeutic cannabis creams.
When talking about the harvests of these cannabis plants, we will know that between 450-500 gr/m2 can be obtained if it is grown indoors and about 500-600 gr/plant if it is grown outdoors. Its effects control the pain and help people with insomnia. The flavors that come out of the buds are citrusy with herbal notes and earthy and lemony aftertastes.
Both in the USA and Canada, the Sour Tsunami cannabis is a weed that is widely used to make creams, oils, and therapeutic weed extracts because it has unique properties such as its great levels of CBD that are between 9% – 11% as well as its lower THC levels (between 7-11%) that also provide medicinal qualities. This strain of cannabis is practically 1:1, that is, it has 1 part of CBD and another part of THC as its main cannabinoids.
Among the different qualities of Sour Tsunami, its production stands out, ranging from 350-400 gr of buds both indoors and outdoors. Another important point is its effects which tend to be creative with happy sensations and good moments of euphoria that are combined with sweet flavors that have notes of pine, citrus, and wood aftertastes. This strain is effective at treating pain and inflammation but does not cause the brain buzz associated with high THC.
Now you know how cannabis-based creams help the skin and you also know the main strains of weed that you can use to make your own cannabis creams, oils, or extracts. Remember to buy cannabis seeds here at Blimburn Seeds with our triple guarantee and fast, discreet, and safe shipments around the world as well as guaranteed quality in each of the strains you want to grow.